The UK's most complete GLP-1 guide
Every Question Answered. Every Side Effect Explained.
- How GLP-1 medications work
- Mounjaro vs Wegovy compared
- Injection instructions
- Side effects & solutions
- What to eat on treatment
- FAQs answered
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Mounjaro Cravings Coming Back — What to Expect
If your appetite-suppressing effects from Mounjaro are wearing off and food cravings are returning, this is a common experience during tirzepatide treatment. Some people find that appetite control naturally reduces over time as their body adjusts to the medication, or as they progress through their dose titration schedule. Understanding why this happens and what options are available can help you manage your weight loss journey effectively with your prescriber's support.
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Enter your height and weight below. Supports both imperial (stone & lbs) and metric (kg). Results include NHS category, healthy weight range, and ethnicity adjustments.
What Is BMI and Why Does It Matter?
Body Mass Index (BMI) is the most widely used screening tool for assessing whether your weight falls within a healthy range. Used by the NHS, GPs, and weight management services across the UK, BMI provides a quick snapshot of your weight relative to your height. The formula is simple: your weight in kilograms divided by your height in metres squared (kg/m²).
While BMI isn't a perfect measure — it doesn't account for muscle mass, bone density, or fat distribution — it remains the standard first step in identifying potential weight-related health risks including type 2 diabetes, cardiovascular disease, high blood pressure, and certain cancers.
The NHS also recommends adjusted thresholds for people of South Asian, Chinese, or Black African heritage — a BMI of 23 or above is classified as overweight, and 27.5 as obese. Our calculator includes this adjustment as a one-click toggle.
Why Appetite Suppression May Reduce Over Time
When you first start Mounjaro or increase to a new dose, the appetite-suppressing effects are often strongest in the first 4–8 weeks. As your body adjusts to the medication, some people experience a gradual reduction in how full or satisfied they feel after meals. This is partly because tolerance can develop — your body becomes accustomed to the signal from the medication.
- The GIP and GLP-1 receptors your body activates may become less responsive over weeks of continuous exposure
- Gastric emptying effects (slowing how quickly food leaves your stomach) often decrease naturally over time, even during continued treatment
- Weight loss itself can alter hunger hormones, sometimes partially reversing the appetite suppression benefit
- Dose underdosing — if you're not on the maximum dose suitable for you, a dose increase may restore stronger appetite control
This does not mean Mounjaro is no longer working for weight loss — many people continue losing weight even when appetite suppression feels less strong. Appetite control is just one mechanism; the medication continues to affect metabolism and fat utilisation.
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How It Works
Three simple steps to understand your weight and take action.
Enter your height and weight in our free calculator. Get your BMI, NHS category, healthy weight range, and ethnicity-adjusted thresholds instantly.
If your BMI suggests you're overweight or obese, explore our GLP-1 calculators to project potential weight loss on Mounjaro or Wegovy.
Use our progress tracker to log your weight weekly, visualise your journey with charts, and stay motivated — all stored privately in your browser.
Free Weight Loss Tools & Guides
Everything you need to understand your weight, explore medication options, and track your progress — completely free.
What to Do If Cravings Return — NHS Guidance
If you're noticing food cravings returning, discuss this with your prescriber rather than stopping or adjusting the dose yourself. Dose adjustment is a common solution: if you're not yet on the maximum dose of tirzepatide (15 mg weekly), your prescriber may recommend increasing to the next dose level after a minimum of 4 weeks. Calculate your personal BMI and projected weight loss potential using our free GLP-1 weight loss calculator to track your progress alongside your prescriber's clinical assessments.
Alongside medication, reinforce behaviour change: return to structured meal planning, track your food intake, increase physical activity, and consider revisiting our progress tracker to monitor both weight and appetite patterns. Many people find that combining lifestyle strategies with appropriate medication dosing provides the best sustained results.
- Dual GIP/GLP-1 receptor agonist
- Up to 22.5% body weight loss (SURMOUNT-1)
- Weekly injection, dose escalation over 20+ weeks
- Available via private prescription in the UK
- Doses: 2.5mg → 5mg → 7.5mg → 10mg → 12.5mg → 15mg
- GLP-1 receptor agonist
- Up to 15–17% body weight loss (STEP trials)
- Weekly injection, 5-step dose escalation
- NHS & private prescription available
- Doses: 0.25mg → 0.5mg → 1mg → 1.7mg → 2.4mg
Mounjaro vs Wegovy: Head-to-Head
A side-by-side comparison of the two most popular GLP-1 weight loss medications available in the UK.
| Feature | Mounjaro | Wegovy |
|---|---|---|
| Drug class | Dual GIP/GLP-1 agonist | GLP-1 agonist |
| Active ingredient | Tirzepatide | Semaglutide |
| Avg. weight loss | 15–22.5% | 12–17% |
| Key trial | SURMOUNT-1 (2022) | STEP 1 (2021) |
| Max dose | 15 mg weekly | 2.4 mg weekly |
| Escalation period | 20–32 weeks | 16–20 weeks |
| Administration | Weekly injection (pen) | Weekly injection (pen) |
| NHS availability | Private prescription only | NHS & private |
| Approx. private cost | £150–£250/month | £150–£300/month |
| Common side effects | Nausea, diarrhoea, constipation | Nausea, vomiting, diarrhoea |
Data sourced from SURMOUNT-1 and STEP 1 clinical trials. Costs are approximate and vary by provider. Always consult a prescriber.
Am I Eligible for Weight Loss Medication?
In the UK, eligibility for GLP-1 weight loss medications like Mounjaro and Wegovy is based on your BMI and overall health profile.
- BMI of 30 or above (obese)
- Age 18 or over
- No contraindicated conditions
- Committed to lifestyle changes
- BMI of 27 or above
- Plus type 2 diabetes
- Or high blood pressure
- Or obstructive sleep apnoea
Use our BMI calculator to check whether your BMI falls within the eligible range.
How We Built These Tools
Every calculator and guide on myweightcheck is built with accuracy and transparency in mind. Our BMI calculator uses the standard WHO formula with NHS-aligned category thresholds. Our GLP-1 projections are modelled on published clinical trial data from SURMOUNT and STEP studies.
All data stays on your device. We don't require sign-ups, and we don't store your health information on any server. Your progress tracker saves data locally in your browser using localStorage, so only you can see it.
We're based in the UK and our tools are designed specifically for UK users — supporting stone & lbs by default, referencing NHS guidelines, using NICE-approved medication data, and linking to GPhC-registered pharmacies.
Frequently Asked Questions
Common questions about BMI, weight loss medications, and our free UK tools.
Is it normal for Mounjaro's appetite suppression to wear off?
Yes, this is relatively common. Some tolerance can develop over weeks or months, and gastric emptying effects naturally reduce over time. This doesn't mean the medication is no longer working for weight loss — it continues to affect metabolism. Your prescriber can assess whether a dose increase might help restore appetite suppression.
Should I stop taking Mounjaro if cravings come back?
No — speak to your prescriber first. Many people continue losing weight even when appetite suppression feels less strong. Your prescriber may recommend a dose increase (if you're not yet on the maximum 15 mg dose) or adjustments to your lifestyle approach alongside the medication.
How long does it take for Mounjaro's effects to reduce?
Appetite suppression is often strongest in weeks 1–8 after starting or increasing dose. Some people notice gradual reduction after 8–12 weeks, though individual experiences vary significantly. This timeline is not the same for everyone.
What if I'm already on the maximum Mounjaro dose and cravings return?
Discuss this with your prescriber — options may include reinforcing lifestyle changes, increasing physical activity, reviewing meal timing and composition, or exploring whether continued medication is still appropriate for your goals. Your GP or prescriber will provide personalised guidance.
Can Mounjaro be combined with other appetite-control approaches?
Yes — your prescriber may recommend combining Mounjaro with behaviour change support, structured meal planning, or referral to a dietitian. NHS tier 3 weight management services often provide multidisciplinary support alongside medication. Discuss all options with your healthcare team.
Ready to take control of your weight loss journey?
Start with a free BMI check, explore your GLP-1 options, or begin tracking your progress today. No sign-up. No cost. Just results.