UK Guide · Evidence-based

Wegovy (Semaglutide) — Complete UK Guide

What is Wegovy?

Wegovy (semaglutide 2.4mg) is a prescription weight management medication approved in the UK. It's a GLP-1 receptor agonist that helps reduce appetite and calorie intake, leading to clinically significant weight loss.

How does it work?

Wegovy mimics the GLP-1 hormone, which is naturally released after eating. It acts on the brain to reduce appetite and feelings of hunger, slows gastric emptying so you feel full longer, and helps regulate blood sugar levels.

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Wegovy doses & expected weight loss

Based on STEP trial data over 68 weeks

DoseAvg Weight LossNotes
0.25mg~3%Starting dose — weeks 1–4
0.5mg~5%Weeks 5–8
1mg~8%Weeks 9–12
1.7mg~11%Weeks 13–16
2.4mg~14.9%Maximum maintenance dose

Dose escalation timeline

Weeks 1–4 — 0.25mgStarting dose
Weeks 5–8 — 0.5mgFirst increase
Weeks 9–12 — 1mgSecond increase
Weeks 13–16 — 1.7mgThird increase
Weeks 17+ — 2.4mgMaximum maintenance dose

Who is eligible?

  • BMI of 30 or above (obese)
  • BMI of 27.5 or above with a weight-related health condition
  • BMI of 23 or above for South Asian patients
  • Must be aged 18 or over
Clinically Backed
Weight Loss

Same-day prescription from a GPhC-registered UK pharmacy. Next-day DPD delivery.

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Side effects

  • Nausea
  • Diarrhoea
  • Constipation
  • Headache
  • Vomiting
  • Abdominal pain
  • Fatigue

Most side effects are temporary and lessen over time as your body adjusts.

Wegovy vs Mounjaro

FeatureWegovyMounjaro
Drug nameSemaglutideTirzepatide
MechanismGLP-1 onlyDual GIP + GLP-1
Max weight loss~14.9%~20.9%
Max dose2.4mg weekly15mg weekly
AdministrationWeekly injectionWeekly injection