The UK's most complete GLP-1 guide
Every Question Answered. Every Side Effect Explained.
- How GLP-1 medications work
- Mounjaro vs Wegovy compared
- Injection instructions
- Side effects & solutions
- What to eat on treatment
- FAQs answered
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Mounjaro Not Suppressing Appetite — What This Means
If Mounjaro isn't suppressing your appetite as expected, you're not alone. Appetite suppression varies significantly between individuals, and understanding how Mounjaro compares to other GLP-1 medications like Wegovy can help you and your prescriber decide on the best approach. This guide explains the mechanism differences, clinical trial data, and practical steps to take if appetite suppression isn't working for you. Use our free GLP-1 weight loss calculator above to see how different medications might project for your weight management goals.
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Calculate Your BMI Instantly
Enter your height and weight below. Supports both imperial (stone & lbs) and metric (kg). Results include NHS category, healthy weight range, and ethnicity adjustments.
What Is BMI and Why Does It Matter?
Body Mass Index (BMI) is the most widely used screening tool for assessing whether your weight falls within a healthy range. Used by the NHS, GPs, and weight management services across the UK, BMI provides a quick snapshot of your weight relative to your height. The formula is simple: your weight in kilograms divided by your height in metres squared (kg/m²).
While BMI isn't a perfect measure — it doesn't account for muscle mass, bone density, or fat distribution — it remains the standard first step in identifying potential weight-related health risks including type 2 diabetes, cardiovascular disease, high blood pressure, and certain cancers.
The NHS also recommends adjusted thresholds for people of South Asian, Chinese, or Black African heritage — a BMI of 23 or above is classified as overweight, and 27.5 as obese. Our calculator includes this adjustment as a one-click toggle.
How Mounjaro and Wegovy Work Differently
Mounjaro (tirzepatide) is a dual GIP and GLP-1 receptor agonist — it activates two hormone pathways simultaneously. This dual mechanism may theoretically provide stronger appetite suppression than single-mechanism medications. However, clinical trial data shows individual responses vary widely.
Wegovy (semaglutide) is a GLP-1-only receptor agonist. Despite having a single mechanism, STEP trial data showed average weight loss of approximately 14.9% body weight at 2.4 mg, which is comparable to Mounjaro's SURMOUNT trial results (approximately 15–21% depending on dose).
- Mounjaro: GIP + GLP-1 dual action; doses range from 2.5 mg to 15 mg weekly
- Wegovy: GLP-1 only; maximum dose 2.4 mg weekly
- Both require once-weekly injections with a KwikPen device
- Individual appetite suppression varies regardless of mechanism
The key point: a more complex mechanism doesn't assures better appetite suppression for every person. Genetics, stomach sensitivity, and individual physiology all play a role.
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How It Works
Three simple steps to understand your weight and take action.
Enter your height and weight in our free calculator. Get your BMI, NHS category, healthy weight range, and ethnicity-adjusted thresholds instantly.
If your BMI suggests you're overweight or obese, explore our GLP-1 calculators to project potential weight loss on Mounjaro or Wegovy.
Use our progress tracker to log your weight weekly, visualise your journey with charts, and stay motivated — all stored privately in your browser.
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Why Appetite Suppression May Not Be Working
If Mounjaro isn't suppressing your appetite as expected, several factors may be involved:
- Dose level: You may still be on a lower dose (2.5 mg, 5 mg, or 7.5 mg). Appetite suppression typically increases as your dose escalates during the titration schedule
- Time on treatment: It can take 2–3 weeks to feel full appetite suppression effects at each new dose
- Individual variation: Not everyone experiences the same degree of appetite suppression — some people feel full quickly, others feel modest changes
- Medication interaction: Other medications, hormonal factors, or underlying conditions may affect appetite signals
- Psychological factors: Stress, boredom eating, or habit may drive food intake regardless of physical appetite
Discuss these factors with your prescriber, who may adjust your dose, check your injection technique, or consider an alternative medication like Wegovy or adjusting your psychological support plan.
- Dual GIP/GLP-1 receptor agonist
- Up to 22.5% body weight loss (SURMOUNT-1)
- Weekly injection, dose escalation over 20+ weeks
- Available via private prescription in the UK
- Doses: 2.5mg → 5mg → 7.5mg → 10mg → 12.5mg → 15mg
- GLP-1 receptor agonist
- Up to 15–17% body weight loss (STEP trials)
- Weekly injection, 5-step dose escalation
- NHS & private prescription available
- Doses: 0.25mg → 0.5mg → 1mg → 1.7mg → 2.4mg
Mounjaro vs Wegovy: Head-to-Head
A side-by-side comparison of the two most popular GLP-1 weight loss medications available in the UK.
| Feature | Mounjaro | Wegovy |
|---|---|---|
| Drug class | Dual GIP/GLP-1 agonist | GLP-1 agonist |
| Active ingredient | Tirzepatide | Semaglutide |
| Avg. weight loss | 15–22.5% | 12–17% |
| Key trial | SURMOUNT-1 (2022) | STEP 1 (2021) |
| Max dose | 15 mg weekly | 2.4 mg weekly |
| Escalation period | 20–32 weeks | 16–20 weeks |
| Administration | Weekly injection (pen) | Weekly injection (pen) |
| NHS availability | Private prescription only | NHS & private |
| Approx. private cost | £150–£250/month | £150–£300/month |
| Common side effects | Nausea, diarrhoea, constipation | Nausea, vomiting, diarrhoea |
Data sourced from SURMOUNT-1 and STEP 1 clinical trials. Costs are approximate and vary by provider. Always consult a prescriber.
Am I Eligible for Weight Loss Medication?
In the UK, eligibility for GLP-1 weight loss medications like Mounjaro and Wegovy is based on your BMI and overall health profile.
- BMI of 30 or above (obese)
- Age 18 or over
- No contraindicated conditions
- Committed to lifestyle changes
- BMI of 27 or above
- Plus type 2 diabetes
- Or high blood pressure
- Or obstructive sleep apnoea
Use our BMI calculator to check whether your BMI falls within the eligible range.
How We Built These Tools
Every calculator and guide on myweightcheck is built with accuracy and transparency in mind. Our BMI calculator uses the standard WHO formula with NHS-aligned category thresholds. Our GLP-1 projections are modelled on published clinical trial data from SURMOUNT and STEP studies.
All data stays on your device. We don't require sign-ups, and we don't store your health information on any server. Your progress tracker saves data locally in your browser using localStorage, so only you can see it.
We're based in the UK and our tools are designed specifically for UK users — supporting stone & lbs by default, referencing NHS guidelines, using NICE-approved medication data, and linking to GPhC-registered pharmacies.
Frequently Asked Questions
Common questions about BMI, weight loss medications, and our free UK tools.
Is Mounjaro stronger than Wegovy for appetite suppression?
Both medications show similar average weight loss in clinical trials (around 15–20% body weight). Mounjaro has a dual GIP+GLP-1 mechanism versus Wegovy's GLP-1-only approach, but individual appetite suppression varies significantly. One is not universally "stronger" — it depends on your personal response.
How long does it take for Mounjaro to suppress appetite?
Appetite suppression typically begins within 2–3 weeks of starting or increasing your dose. Full effects may take several weeks. The standard dose titration schedule allows 4 weeks at each dose level before increasing, giving time for appetite effects to stabilise.
What should I do if Mounjaro isn't suppressing my appetite?
Contact your prescriber. Options include: waiting longer at your current dose, increasing to the next dose level, checking injection technique, or discussing a switch to Wegovy or other medications. Your prescriber will assess what's best for you.
Can I switch from Mounjaro to Wegovy if appetite suppression isn't working?
Potentially, yes. This must be managed by your prescriber. Approximate dose equivalences exist (5 mg Mounjaro ≈ 0.5 mg Wegovy; 15 mg Mounjaro ≈ 2.4 mg Wegovy), but switching is individualised and requires clinical guidance. Do not change medications without your prescriber's approval.
Does diet affect how well Mounjaro suppresses appetite?
Yes. GLP-1 medications work best alongside a reduced-calorie diet and increased physical activity. If you're eating high-calorie foods or very large meals, appetite suppression effects may be less noticeable. Use our free progress tracker to log your diet alongside your treatment to identify patterns.
Ready to take control of your weight loss journey?
Start with a free BMI check, explore your GLP-1 options, or begin tracking your progress today. No sign-up. No cost. Just results.