The UK's most complete GLP-1 guide
Every Question Answered. Every Side Effect Explained.
- How GLP-1 medications work
- Mounjaro vs Wegovy compared
- Injection instructions
- Side effects & solutions
- What to eat on treatment
- FAQs answered
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Understanding Mounjaro Titration Schedule
Mounjaro titration is the gradual increase in your tirzepatide dose over several weeks to help your body adjust to the medication and find the dose that works best for you. In the UK, Mounjaro is a prescription-only weight management injection that requires a structured titration schedule starting at 2.5 mg once weekly. Your prescriber will guide you through each dose increase based on your tolerance and response. This informational guide explains how the UK titration process works and what you can expect during treatment.
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What Is BMI and Why Does It Matter?
Body Mass Index (BMI) is the most widely used screening tool for assessing whether your weight falls within a healthy range. Used by the NHS, GPs, and weight management services across the UK, BMI provides a quick snapshot of your weight relative to your height. The formula is simple: your weight in kilograms divided by your height in metres squared (kg/m²).
While BMI isn't a perfect measure — it doesn't account for muscle mass, bone density, or fat distribution — it remains the standard first step in identifying potential weight-related health risks including type 2 diabetes, cardiovascular disease, high blood pressure, and certain cancers.
The NHS also recommends adjusted thresholds for people of South Asian, Chinese, or Black African heritage — a BMI of 23 or above is classified as overweight, and 27.5 as obese. Our calculator includes this adjustment as a one-click toggle.
How Mounjaro Dose Titration Works in the UK
Mounjaro titration follows a structured schedule approved for use in UK specialist weight management services and through private prescription. You start at a low dose and gradually increase every 4 weeks until reaching your maintenance or target dose. The standard UK titration schedule is:
- Weeks 1–4: 2.5 mg once weekly (starting dose)
- Weeks 5–8: 5 mg once weekly (first escalation)
- Weeks 9–12: 7.5 mg once weekly
- Weeks 13–16: 10 mg once weekly
- Weeks 17–20: 12.5 mg once weekly
- Week 21+: 15 mg once weekly (maximum dose)
Each dose is delivered as a once-weekly injection using the KwikPen device. You must remain on each dose for a minimum of 4 weeks before escalating. If you experience significant side effects, your prescriber may delay or pause the titration schedule. Not everyone reaches the maximum 15 mg dose—many patients achieve their weight loss goals at lower maintenance doses like 5 mg, 7.5 mg, or 10 mg. Your prescriber will assess your individual tolerance and progress to determine the right dose for you.
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How It Works
Three simple steps to understand your weight and take action.
Enter your height and weight in our free calculator. Get your BMI, NHS category, healthy weight range, and ethnicity-adjusted thresholds instantly.
If your BMI suggests you're overweight or obese, explore our GLP-1 calculators to project potential weight loss on Mounjaro or Wegovy.
Use our progress tracker to log your weight weekly, visualise your journey with charts, and stay motivated — all stored privately in your browser.
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Side Effects and Titration — What to Expect
During titration, side effects like nausea, diarrhoea, and reduced appetite are common, particularly in the first 1–2 weeks after each dose increase. These effects often improve or settle after a few days as your body adjusts. Important: if you experience severe, persistent stomach pain spreading to your back (possible sign of pancreatitis), serious allergic reactions, or other concerning symptoms, contact your prescriber or NHS 111 immediately.
Use our free GLP-1 weight loss calculator to understand potential outcomes at different tirzepatide doses based on clinical trial data. Combining this with regular progress tracking helps you and your prescriber assess whether to continue escalating or maintain your current dose.
- Dual GIP/GLP-1 receptor agonist
- Up to 22.5% body weight loss (SURMOUNT-1)
- Weekly injection, dose escalation over 20+ weeks
- Available via private prescription in the UK
- Doses: 2.5mg → 5mg → 7.5mg → 10mg → 12.5mg → 15mg
- GLP-1 receptor agonist
- Up to 15–17% body weight loss (STEP trials)
- Weekly injection, 5-step dose escalation
- NHS & private prescription available
- Doses: 0.25mg → 0.5mg → 1mg → 1.7mg → 2.4mg
Mounjaro vs Wegovy: Head-to-Head
A side-by-side comparison of the two most popular GLP-1 weight loss medications available in the UK.
| Feature | Mounjaro | Wegovy |
|---|---|---|
| Drug class | Dual GIP/GLP-1 agonist | GLP-1 agonist |
| Active ingredient | Tirzepatide | Semaglutide |
| Avg. weight loss | 15–22.5% | 12–17% |
| Key trial | SURMOUNT-1 (2022) | STEP 1 (2021) |
| Max dose | 15 mg weekly | 2.4 mg weekly |
| Escalation period | 20–32 weeks | 16–20 weeks |
| Administration | Weekly injection (pen) | Weekly injection (pen) |
| NHS availability | Private prescription only | NHS & private |
| Approx. private cost | £150–£250/month | £150–£300/month |
| Common side effects | Nausea, diarrhoea, constipation | Nausea, vomiting, diarrhoea |
Data sourced from SURMOUNT-1 and STEP 1 clinical trials. Costs are approximate and vary by provider. Always consult a prescriber.
Am I Eligible for Weight Loss Medication?
In the UK, eligibility for GLP-1 weight loss medications like Mounjaro and Wegovy is based on your BMI and overall health profile.
- BMI of 30 or above (obese)
- Age 18 or over
- No contraindicated conditions
- Committed to lifestyle changes
- BMI of 27 or above
- Plus type 2 diabetes
- Or high blood pressure
- Or obstructive sleep apnoea
Use our BMI calculator to check whether your BMI falls within the eligible range.
How We Built These Tools
Every calculator and guide on myweightcheck is built with accuracy and transparency in mind. Our BMI calculator uses the standard WHO formula with NHS-aligned category thresholds. Our GLP-1 projections are modelled on published clinical trial data from SURMOUNT and STEP studies.
All data stays on your device. We don't require sign-ups, and we don't store your health information on any server. Your progress tracker saves data locally in your browser using localStorage, so only you can see it.
We're based in the UK and our tools are designed specifically for UK users — supporting stone & lbs by default, referencing NHS guidelines, using NICE-approved medication data, and linking to GPhC-registered pharmacies.
Frequently Asked Questions
Common questions about BMI, weight loss medications, and our free UK tools.
Can I skip a dose during Mounjaro titration if I'm experiencing side effects?
No—do not skip doses. If you're experiencing side effects, contact your prescriber immediately. They may pause your titration at the current dose for an extra week or two before escalating, allowing your body more time to adjust. Never adjust your dose without guidance from your prescriber.
How long does the full Mounjaro titration schedule take?
The full titration from 2.5 mg to the maximum 15 mg dose takes approximately 20–21 weeks (5 months). However, many people reach their weight loss goals at lower doses and may not progress beyond 7.5 mg or 10 mg, so the actual timeline varies by individual.
What is the difference between Mounjaro titration and Wegovy titration?
Mounjaro (tirzepatide) and Wegovy (semaglutide) are different medications with different titration schedules. Mounjaro starts at 2.5 mg and increases by 2.5 mg increments to a maximum of 15 mg. Wegovy starts at 0.25 mg and increases by smaller increments to a maximum of 2.4 mg. Ask your prescriber which is appropriate for your situation.
If I miss a Mounjaro injection during titration, what should I do?
If you miss a dose, take it as soon as you remember if it's within 4 days of the missed dose. If more than 4 days have passed, skip that dose and take your next dose on the scheduled day. Never take two doses close together—maintain at least 72 hours between injections.
Will I always need to continue escalating during Mounjaro titration?
No. Your prescriber will assess your weight loss progress, side effects, and how you're tolerating the medication at each dose level. Many people achieve their goals at 5 mg, 7.5 mg, or 10 mg and remain on that maintenance dose long-term rather than escalating to 15 mg.
Ready to take control of your weight loss journey?
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