The UK's most complete GLP-1 guide
Every Question Answered. Every Side Effect Explained.
- How GLP-1 medications work
- Mounjaro vs Wegovy compared
- Injection instructions
- Side effects & solutions
- What to eat on treatment
- FAQs answered
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Mounjaro Titration — Complete UK Dose Schedule
Mounjaro titration is the gradual escalation of your tirzepatide dose over several weeks to help your body adjust whilst minimising side effects. In the UK, Mounjaro is prescribed following a clinical assessment through NHS specialist services or private prescribing. The standard titration schedule starts at 2.5 mg and increases every four weeks up to a maximum of 15 mg. Understanding how titration works helps you know what to expect from your treatment and manage any temporary side effects as your body adapts to each new dose level.
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Enter your height and weight below. Supports both imperial (stone & lbs) and metric (kg). Results include NHS category, healthy weight range, and ethnicity adjustments.
What Is BMI and Why Does It Matter?
Body Mass Index (BMI) is the most widely used screening tool for assessing whether your weight falls within a healthy range. Used by the NHS, GPs, and weight management services across the UK, BMI provides a quick snapshot of your weight relative to your height. The formula is simple: your weight in kilograms divided by your height in metres squared (kg/m²).
While BMI isn't a perfect measure — it doesn't account for muscle mass, bone density, or fat distribution — it remains the standard first step in identifying potential weight-related health risks including type 2 diabetes, cardiovascular disease, high blood pressure, and certain cancers.
The NHS also recommends adjusted thresholds for people of South Asian, Chinese, or Black African heritage — a BMI of 23 or above is classified as overweight, and 27.5 as obese. Our calculator includes this adjustment as a one-click toggle.
How Mounjaro Titration Works in the UK
Mounjaro titration is a structured approach designed to help your body adapt gradually whilst reducing the intensity of digestive side effects, particularly nausea and vomiting. Rather than starting at the maximum dose, your prescriber introduces tirzepatide at a low concentration and increases it in controlled steps. Each step lasts a minimum of four weeks, allowing your system to adjust before escalating further.
- Week 1–4: 2.5 mg once weekly (starting dose)
- Week 5–8: 5 mg once weekly (first escalation)
- Week 9–12: 7.5 mg once weekly
- Week 13–16: 10 mg once weekly
- Week 17–20: 12.5 mg once weekly
- Week 21+: 15 mg once weekly (maximum maintenance dose)
Your prescriber may recommend staying at a lower dose if you're achieving good weight loss results, as clinical evidence shows significant benefits at 5 mg and 10 mg. The Mounjaro KwikPen makes self-administration straightforward once weekly on the same day each week.
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How It Works
Three simple steps to understand your weight and take action.
Enter your height and weight in our free calculator. Get your BMI, NHS category, healthy weight range, and ethnicity-adjusted thresholds instantly.
If your BMI suggests you're overweight or obese, explore our GLP-1 calculators to project potential weight loss on Mounjaro or Wegovy.
Use our progress tracker to log your weight weekly, visualise your journey with charts, and stay motivated — all stored privately in your browser.
Free Weight Loss Tools & Guides
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NHS Eligibility and Prescribing Context
NICE has approved tirzepatide (Mounjaro) for weight management in UK adults through NHS specialist tier 3 and tier 4 weight management services. NHS eligibility typically requires a BMI of 30 or above, or 27–29.9 with weight-related health conditions such as type 2 diabetes, hypertension, or sleep apnoea. Access is through specialist referral rather than standard GP prescription, and availability varies significantly by region. Waiting lists for NHS specialist services can be lengthy in many areas. Alternatively, tirzepatide is available through private online prescribing following a clinical assessment with a UK-licensed prescriber, offering faster access but at personal cost. Either route requires your prescriber to assess suitability based on your individual health profile before starting any titration schedule.
- Dual GIP/GLP-1 receptor agonist
- Up to 22.5% body weight loss (SURMOUNT-1)
- Weekly injection, dose escalation over 20+ weeks
- Available via private prescription in the UK
- Doses: 2.5mg → 5mg → 7.5mg → 10mg → 12.5mg → 15mg
- GLP-1 receptor agonist
- Up to 15–17% body weight loss (STEP trials)
- Weekly injection, 5-step dose escalation
- NHS & private prescription available
- Doses: 0.25mg → 0.5mg → 1mg → 1.7mg → 2.4mg
Mounjaro vs Wegovy: Head-to-Head
A side-by-side comparison of the two most popular GLP-1 weight loss medications available in the UK.
| Feature | Mounjaro | Wegovy |
|---|---|---|
| Drug class | Dual GIP/GLP-1 agonist | GLP-1 agonist |
| Active ingredient | Tirzepatide | Semaglutide |
| Avg. weight loss | 15–22.5% | 12–17% |
| Key trial | SURMOUNT-1 (2022) | STEP 1 (2021) |
| Max dose | 15 mg weekly | 2.4 mg weekly |
| Escalation period | 20–32 weeks | 16–20 weeks |
| Administration | Weekly injection (pen) | Weekly injection (pen) |
| NHS availability | Private prescription only | NHS & private |
| Approx. private cost | £150–£250/month | £150–£300/month |
| Common side effects | Nausea, diarrhoea, constipation | Nausea, vomiting, diarrhoea |
Data sourced from SURMOUNT-1 and STEP 1 clinical trials. Costs are approximate and vary by provider. Always consult a prescriber.
Am I Eligible for Weight Loss Medication?
In the UK, eligibility for GLP-1 weight loss medications like Mounjaro and Wegovy is based on your BMI and overall health profile.
- BMI of 30 or above (obese)
- Age 18 or over
- No contraindicated conditions
- Committed to lifestyle changes
- BMI of 27 or above
- Plus type 2 diabetes
- Or high blood pressure
- Or obstructive sleep apnoea
Use our BMI calculator to check whether your BMI falls within the eligible range.
How We Built These Tools
Every calculator and guide on myweightcheck is built with accuracy and transparency in mind. Our BMI calculator uses the standard WHO formula with NHS-aligned category thresholds. Our GLP-1 projections are modelled on published clinical trial data from SURMOUNT and STEP studies.
All data stays on your device. We don't require sign-ups, and we don't store your health information on any server. Your progress tracker saves data locally in your browser using localStorage, so only you can see it.
We're based in the UK and our tools are designed specifically for UK users — supporting stone & lbs by default, referencing NHS guidelines, using NICE-approved medication data, and linking to GPhC-registered pharmacies.
Frequently Asked Questions
Common questions about BMI, weight loss medications, and our free UK tools.
Why does Mounjaro titration take so long?
Gradual titration allows your digestive system to adapt to tirzepatide's effects, reducing the severity of nausea and other side effects. Starting at 2.5 mg and increasing every four weeks helps your body acclimatise whilst your prescriber monitors your response and tolerability.
Can I skip doses during titration or stay at a lower dose?
Yes — if you're experiencing significant weight loss and appetite reduction at a lower dose (e.g. 5 mg or 10 mg), your prescriber may recommend you stay at that level rather than escalating further. Titration is flexible based on your individual response. Never skip a scheduled dose without consulting your prescriber.
What if I miss a dose during titration?
If you miss a dose within 4 days, take it as soon as you remember and continue your normal schedule the following week. If more than 4 days have passed, skip that dose and take your next injection on the regular scheduled day. Never double-dose.
How does Mounjaro titration compare to Wegovy's dose schedule?
Mounjaro starts at 2.5 mg and escalates to a maximum of 15 mg weekly, whilst Wegovy (semaglutide) starts at 0.25 mg and escalates to 2.4 mg weekly. Mounjaro's titration progresses more slowly, and the maximum maintenance dose is significantly higher. Both require four-week intervals between dose increases.
Will my GP manage my Mounjaro titration, or do I need a specialist?
In most NHS cases, a tier 3 specialist weight management service manages titration. Through private prescribing, your UK-licensed prescriber oversees the process via online consultation. Your GP may provide supportive care, but typically does not initiate or manage the titration schedule directly.
Ready to take control of your weight loss journey?
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