The UK's most complete GLP-1 guide
Every Question Answered. Every Side Effect Explained.
- How GLP-1 medications work
- Mounjaro vs Wegovy compared
- Injection instructions
- Side effects & solutions
- What to eat on treatment
- FAQs answered
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What Is Appetite Suppression on Mounjaro?
Appetite suppression on Mounjaro refers to how the medication reduces hunger signals and helps you feel fuller after eating smaller meals. Unlike Wegovy, which uses a single GLP-1 mechanism, Mounjaro (tirzepatide) works as a dual GIP and GLP-1 receptor agonist — this dual action may contribute to stronger appetite suppression for some people. Understanding how this suppression works can help you manage expectations when considering this prescription-only weight management injection. Try our GLP-1 weight loss calculator to estimate potential outcomes based on the medication's mechanism.
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Calculate Your BMI Instantly
Enter your height and weight below. Supports both imperial (stone & lbs) and metric (kg). Results include NHS category, healthy weight range, and ethnicity adjustments.
What Is BMI and Why Does It Matter?
Body Mass Index (BMI) is the most widely used screening tool for assessing whether your weight falls within a healthy range. Used by the NHS, GPs, and weight management services across the UK, BMI provides a quick snapshot of your weight relative to your height. The formula is simple: your weight in kilograms divided by your height in metres squared (kg/m²).
While BMI isn't a perfect measure — it doesn't account for muscle mass, bone density, or fat distribution — it remains the standard first step in identifying potential weight-related health risks including type 2 diabetes, cardiovascular disease, high blood pressure, and certain cancers.
The NHS also recommends adjusted thresholds for people of South Asian, Chinese, or Black African heritage — a BMI of 23 or above is classified as overweight, and 27.5 as obese. Our calculator includes this adjustment as a one-click toggle.
How Appetite Suppression Works: Mounjaro vs Wegovy
Mounjaro's dual mechanism: Mounjaro activates both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 receptor pathways. GIP helps regulate fat utilisation and may amplify appetite suppression, whilst GLP-1 signals fullness to the brain. Clinical trials (SURMOUNT-1) showed average weight loss of 20.9% at the maximum 15 mg dose — results that may reflect stronger appetite suppression compared to single-mechanism medications.
Wegovy's single mechanism: Wegovy uses GLP-1 only, activating the fullness signal without GIP activation. STEP-1 trial data showed average weight loss of approximately 14.9% at the maximum 2.4 mg dose. Both medications slow gastric emptying, but the dual action in Mounjaro may produce more pronounced appetite suppression for some users.
- Mounjaro: dual GIP+GLP-1 = potentially stronger suppression
- Wegovy: GLP-1 only = effective but single-pathway
- Individual response varies significantly
- Both require a reduced-calorie diet and increased physical activity
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How It Works
Three simple steps to understand your weight and take action.
Enter your height and weight in our free calculator. Get your BMI, NHS category, healthy weight range, and ethnicity-adjusted thresholds instantly.
If your BMI suggests you're overweight or obese, explore our GLP-1 calculators to project potential weight loss on Mounjaro or Wegovy.
Use our progress tracker to log your weight weekly, visualise your journey with charts, and stay motivated — all stored privately in your browser.
Free Weight Loss Tools & Guides
Everything you need to understand your weight, explore medication options, and track your progress — completely free.
Choosing Between Mounjaro and Wegovy for Appetite Control
Appetite suppression intensity varies between individuals — what works powerfully for one person may feel moderate for another. Neither medication is "stronger" in absolute terms; rather, the dual mechanism in Mounjaro may suit some patients better, whilst others respond equally well to Wegovy's single GLP-1 pathway. A UK-licensed prescriber will assess your individual health, medical history, and previous weight loss attempts to recommend the most suitable option. Use our BMI calculator to establish your baseline, then discuss eligibility and mechanism preferences with your GP or specialist weight management service before prescription.
- Dual GIP/GLP-1 receptor agonist
- Up to 22.5% body weight loss (SURMOUNT-1)
- Weekly injection, dose escalation over 20+ weeks
- Available via private prescription in the UK
- Doses: 2.5mg → 5mg → 7.5mg → 10mg → 12.5mg → 15mg
- GLP-1 receptor agonist
- Up to 15–17% body weight loss (STEP trials)
- Weekly injection, 5-step dose escalation
- NHS & private prescription available
- Doses: 0.25mg → 0.5mg → 1mg → 1.7mg → 2.4mg
Mounjaro vs Wegovy: Head-to-Head
A side-by-side comparison of the two most popular GLP-1 weight loss medications available in the UK.
| Feature | Mounjaro | Wegovy |
|---|---|---|
| Drug class | Dual GIP/GLP-1 agonist | GLP-1 agonist |
| Active ingredient | Tirzepatide | Semaglutide |
| Avg. weight loss | 15–22.5% | 12–17% |
| Key trial | SURMOUNT-1 (2022) | STEP 1 (2021) |
| Max dose | 15 mg weekly | 2.4 mg weekly |
| Escalation period | 20–32 weeks | 16–20 weeks |
| Administration | Weekly injection (pen) | Weekly injection (pen) |
| NHS availability | Private prescription only | NHS & private |
| Approx. private cost | £150–£250/month | £150–£300/month |
| Common side effects | Nausea, diarrhoea, constipation | Nausea, vomiting, diarrhoea |
Data sourced from SURMOUNT-1 and STEP 1 clinical trials. Costs are approximate and vary by provider. Always consult a prescriber.
Am I Eligible for Weight Loss Medication?
In the UK, eligibility for GLP-1 weight loss medications like Mounjaro and Wegovy is based on your BMI and overall health profile.
- BMI of 30 or above (obese)
- Age 18 or over
- No contraindicated conditions
- Committed to lifestyle changes
- BMI of 27 or above
- Plus type 2 diabetes
- Or high blood pressure
- Or obstructive sleep apnoea
Use our BMI calculator to check whether your BMI falls within the eligible range.
How We Built These Tools
Every calculator and guide on myweightcheck is built with accuracy and transparency in mind. Our BMI calculator uses the standard WHO formula with NHS-aligned category thresholds. Our GLP-1 projections are modelled on published clinical trial data from SURMOUNT and STEP studies.
All data stays on your device. We don't require sign-ups, and we don't store your health information on any server. Your progress tracker saves data locally in your browser using localStorage, so only you can see it.
We're based in the UK and our tools are designed specifically for UK users — supporting stone & lbs by default, referencing NHS guidelines, using NICE-approved medication data, and linking to GPhC-registered pharmacies.
Frequently Asked Questions
Common questions about BMI, weight loss medications, and our free UK tools.
Does Mounjaro suppress appetite more than Wegovy?
Clinical trial data suggests Mounjaro's dual GIP+GLP-1 mechanism may produce stronger average weight loss (20.9% vs 14.9%), which could indicate more pronounced appetite suppression for some users. However, individual responses vary significantly — some people achieve excellent appetite control on Wegovy. Your prescriber will assess which is most suitable for you based on your personal health profile and medical history.
How long does appetite suppression take on Mounjaro?
Appetite suppression typically begins within the first 1–2 weeks of starting Mounjaro, with effects often becoming more noticeable as you titrate through doses (increasing every 4 weeks). Maximum suppression is usually achieved once you reach a stable maintenance dose. Individual timelines vary — some people notice effects immediately, whilst others experience gradual changes over several weeks.
What happens to appetite suppression over time on Mounjaro?
Appetite suppression generally remains consistent on a stable Mounjaro dose. Some people experience slight tolerance (reduced effect) over months, though this is not universal. Gastric emptying effects (slowed stomach emptying) may reduce over time. If suppression decreases, your prescriber may adjust your dose or discuss ongoing suitability of treatment with you.
Is appetite suppression on Mounjaro the same as not eating?
No — Mounjaro's appetite suppression is different from restricting calories through willpower. The medication reduces hunger signals and increases fullness, but you can still eat normally if you choose. The goal is to eat appropriate portions without constant hunger, not to suppress appetite to dangerous levels. Always eat regular, nutritious meals alongside the medication.
Can appetite suppression on Mounjaro stop working?
Appetite suppression typically remains effective on a stable dose, though some tolerance is possible over extended periods. If you notice reduced suppression, discuss this with your prescriber — they may adjust your dose, assess medication adherence, or review your overall weight management plan. Individual responses vary, and your GP can provide personalised guidance.
Ready to take control of your weight loss journey?
Start with a free BMI check, explore your GLP-1 options, or begin tracking your progress today. No sign-up. No cost. Just results.